Alcohol and Hormones by Ronald R. Watson (auth.), Ronald R. Watson (eds.)

By Ronald R. Watson (auth.), Ronald R. Watson (eds.)

Alcoholism, the oldest addictive affliction, continues to be a significant challenge due to its significant variations of many physiological platforms. The genetic and neurological origins and mechanisms are advanced and in simple terms in part understood. although, it's transparent that alcohol use modifies the creation of so much hormones, without delay and ultimately modulating the platforms that hormones control. Acute and protracted alcohol intake impacts almost all mobile services of tissues like mind, liver, immune process, and reproductive and endocrine organs. The latter have significant regula­ tory roles, affecting many services from improvement to repro­ duction. even supposing tension can additional regulate alcohol's results on hormone creation, it considerably factors such a lot of alcohol's modi­ fications of the physique to ensue through alterations in hormone construction and secretion. Ronald R. Watson vii members Michael L. Adams • division of Psychiatry, Washington college college of drugs, St. Louis, MO Robert A. Anderson, Jr .• Ob/Gyn learn, Rush-Presbyterian-St. Luke's scientific middle, Chicago,IL Kasibhatla Bhavani • Molecular Heptology Laboratory, Massachusetts normal sanatorium melanoma heart, Harvard scientific tuition, Charlestown, MA Theodore J. Cicero • division of Psychiatry, Washington collage university of medication, St.

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Ontogeny One particularly promising approach to help in distinguishing whether there are one or more opioid receptor SUbtypes involved in endocrine function is to study the developmental time-course for the appearance of their endocrine effects. Theoretically, if two or more opioid receptors are involved Opioid-Mediated Control 29 in the regulation of activity in a specific endocrine system, one would predict that they would develop at different rates, which can be correlated with various aspects of the maturation of endocrine responses.

Specifically, in the developing animal, rapid and clearly identifiable changes occur in the relative activity of a number of neuronal systems, as opposed to the adult animal in which all systems function interactively. It would seem plausible to suggest that studies of opiate pharmacology in animals during this rapid phase of development might afford significant opportunities to draw meaningful comparisons between the development of tolerance and the maturation of specific elements or systems in the central nervous system.

The effects of selective blockers for ~-endorphin (1l/E), 11, lC, and 8 receptors on stressinduced increases in serum prolactin levels revealed, in agreement with the experiments utilizing antibodies, that antagonists selective for ~-endorphin, 11, and lC receptors markedly reduced the stress-induced increases in serum PRL levels; 8 receptor antagonists once again had no discernible effects on the prolactin response to stress. l. and K receptors are involved in the stress-induced increases in serum prolactin levels in the male rat, but that 8 receptors probably play no significant role in these effects.

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