Antibiotics: Containing the Beta-Lactam Structure by E. P. Abraham (auth.), Professor Dr. Arnold L. Demain, Ms.

By E. P. Abraham (auth.), Professor Dr. Arnold L. Demain, Ms. Nadine A. Solomon (eds.)

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Coli: amidase (1); transglycosylase (2); glucosarninidase (3); L,D carboxypeptidase (4); D,D carboxypeptidase (5); and endopeptidase (6). The bottom part of the figure shows the structure of the bactoprenol-linked disaccharide-pentapeptide cell wall precursor. The tentative structure of the murein of the Archaebacterium is from HAMMES and KANDLER (1976) Mode of Action of ,B-Lactam Antibiotics - A Microbiologist's View 23 id cell wall that can be isolated and can be shown to retain the size and shape of the original bacterium (HAMMES et al.

In order to provide a proper discussion of these questions, we must first briefly survey the various lines of study that led to the identification of the penicillin-sensitive reactions in the bacterial cell. c. The Biochemical Targets of ft-Lactam Antibiotics Within about a decade after the isolation of penicillin, much of the chemistry of this class of compounds has been elucidated. However, this did not offer much help in the search for the targets of these drugs. The first important clues concerning the nature of the biochemical targets of penicillin in the bacterial cell came from findings concerning the selective toxicity of fJ-lactams to procaryotic cells, the localization of radioactively labeled penicillin in bacteria, and the morphological and biochemical effects of penicillin.

5 E. 0 4 E. 0 2 E. coli DC2 permeab. 6 E. coli DC2 RP1 permeab. 16 P. aeruginosa K 799/61 permeab. 1 8 Organism I HOOVER and DUNN (1979) HOOVER and DUNN (1979) PASCULLE et al. 5 CURTIS and Ross (1980) HARTMAN and TOMASZ (1980) SHOCKMAN et al. (1981) SHOCKMAN et al. 4 Thienamycin MK0787 Table 1. The minimal inhibitory concentrations of some fj-Iactam antibiotics against a variety of bacteria ~ () ~ ::;1 ~ '" ~ '" 1(9. 0- o· 0 c:r" ~r ~ >- '"I ::to () o· 5' ::s. -.. , (1) 0 p. 22 A. ToMASZ ... IU 11' i (L)Ala 1 l' (L)Lya - - (LlGlu 1 (M)Dap--(D)Ala 4·ql (D)Ala s·ql (D)Ala 1J 8.

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