Apolipoprotein E and Alzheimer’s Disease (Research and by A.D. Roses, K.H. Weisgraber, Y. Christen

By A.D. Roses, K.H. Weisgraber, Y. Christen

There's now enormous genetic facts that the sort four allele of the apolipoprotein E gene is a huge susceptibility issue linked to late-onset Alzheimer's affliction, the typical kind of the ailment outlined as beginning after sixty years of age. The function of apolipoprotein E in common mind metabolism and within the pathogenesis of Alzheimer's affliction are new and interesting avenues of study. This publication, written via the main impressive scientists during this new box, is the 1st presentation of effects in regards to the implications of apolipoprotein E at the genetics, mobile biology, neuropathology, biochemistry, and healing administration of Alzheimer's illness.

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Additional info for Apolipoprotein E and Alzheimer’s Disease (Research and Perspectives in Alzheimer's Disease)

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The three major APOE alleles confer specific genetic susceptibility for the onset of Alzheimer's Disease (AD: Strittmatter et al. 1993a; Saunders et al. 1993a,b; Corder et al. 1993,1994). BesIdes its known role in cholesterol transport in the periphery (Mahley 1988), apoE is also synthesized in the central nervous system by astrocytes and other glial derivatives, and participates in synaptic remodeling and repair and response to nervous system injury (Skene and Shooter 1983; Muller et al. 1985; Snipes et al.

In very old mice and some adult rats, occasional neurons were observed with faint immunoreactivity similar to the faint neurons illustrated in Fig. 8A,B. Often, such apoE-immunoreactive neurons were surrounded by a much more intense apoE immunoreactive net. The availability of APOE knockout animals afforded an excellent test of specificity of apoE immunoreactivity. Tissue sections from liver of apoE knockout animals were unstained except for background compared to sections from wild-type litter mates obtained from heterozygote breeding processed in parallel (Fig.

Trends Neuroscl 12 525-530 Pamer 1, Hess M, May PC, Fmch CE (1991a) Clonmg of hIppocampal poly(A +) RNA sequences that mcrease after entorhmal cortex leSIOn m adult rat Mol Bram Res 9: 191-195 Pomer 1, Hess M, May PC, Fmch CE (1991b) Apohpoprotem E and GFAP-RNA m hIppocampus dunng reacttve synaptogenesls and termmal prohferatlOn. Mol Brain Res II 97-106 Pomer 1, Bacclchet A, Dea D, GauthIer S (1993a) Role of hIppocampal cholesterol syntheSIS and uptake dunng reacttve synaptogenesls In adult rats NeurOSCIence 55 81-90 Pomer 1, DaVIgnon 1, Bouthllher D, Bertrand P, GauthIer S (1993b) Apohpoprotein E and AlzheImer's dIsease Lancet 342 697"'{)99 Pomer 1, Aubert I, Bertrand p, QUlflon R, GauthIer S, Nalbantoglu 1 (1994) ApohpoproteIn E4 and chohnerglc dysfunctton In AD a role for the amylOld/apoE4 complex?

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