By Bo Qi Liu, Bing Li (auth.), Guo Jun Huang BS, MD, FCCP, Ying K’ai Wu MB, ChB, FACS (Hon) (eds.)
This ebook has its roots in a monograph on melanoma of the esophagus and gastric cardia edited through us in 1965 and released in chinese language on ly. besides a few colleagues in quite a few fields, we summa rized our paintings within the epidemiology, pathology, prognosis, radiother apy, and surgical procedure of carcinoma of the esophagus and gastric cardia, performed mainly at Peking Union scientific collage health facility, Fu wai sanatorium, and the melanoma Institute of the chinese language Academy of scientific Sciences throughout the 25 years from 1939 to 1964. within the 18 years because the book of that monograph, additional development has been made in China in a number of elements of study and surgical operation. ample fabric has been gathered at the lengthy time period result of surgical procedure, and a couple of more moderen ideas and meth ods for analysis and administration were developed. which will meet the necessity for the alternate of clinical and technical informa tion, either regionally and the world over, we've got invited a bunch of our present colleagues engaged on the various elements of carci noma of the esophagus and gastric cardia to give a contribution to the pre despatched quantity, that is being published in either chinese language and English. The chinese language variation, just like the unique monograph, is being post ed through Shanghai technological know-how and know-how Publishers. throughout the sort invitation of Dr. Heinz Gotze, the English textual content is being post ed for overseas move by means of Springer-Verlag.
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The results indicate the possible presence ofmutagen(s) and promoter(s) in the moldy foods . A preliminary study of the potential causative factors of esophageal and forestomach tumors contained in the moldy food was carried out by Zhang and He , who reported for the first time the induction of forestomach papilloma in rats fed with Fusarium-inoculated food. Researchers at Hebei Medical College (1972-1974) noted the development of hyperplasia and papillomatous lesions in the esophagus and forestomach of mice after prolonged feeding with fungi-contaminated dried sweet potato, dried radish, and pickled vegetable juice.
In 1958, Howell, Evans et al.  reported 18 cases of esophageal carcinoma in three generations of two families in Liverpool. In 17 cases there was unequivocal evidence of associated tylosis (keratosis) palmaris et plantaris, and tylosis may have been present in the remaining case. Of the other 86 family members in whom tylosis was not identified, only one had carcinoma of the esophagus. Follow-up of these families has shown a continued high rate of esophageal cancer in the tylotic family members and no cases among their nontylotic relatives.
3 Opium Hewer et al.  have reported that opium addiction is widespread in northeast Iran; both crude opium and opium dross (sukhteh) are eaten in considerable quantities. In part of the Transkei, various tobacco residues from the bowl or stem of the pipe are eaten or chewed. Hewer et al. showed that these pyrolyzed substances displayed mutagenic activity in Salmonella typhimurium strains T~8 and TA100 in the presence of rat liver micro somes. Further investigation on the isolation and characterization of the mutagenic compounds formed during opium pyrolysis, smoke condensates from pyrolysis of the major alkaloid constituents of opium, was undertaken at the International Agency for Research on Cancer.