Formation and Regeneration of Nerve Connections by Marcus Jacobson (auth.), Sansar C. Sharma, James W. Fawcett

By Marcus Jacobson (auth.), Sansar C. Sharma, James W. Fawcett (eds.)

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Nature New Biol 238: 286-287 Sperry RW (1944): Optic nerve regeneration with return of vision in anurans. J Neurophysiol7: 57--69 Sperry RW (1963) Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc Natl Acad Sci USA 50:703-707. Straznicky C, Gaze RM (1971): The growth of the retina in Xenopus laevis: An autoradiographic study. J Embryol Exp Morphol26: 67-79 Straznicky C, Gaze RM (1972): The development of the tectum in Xenopus laevis: An autoradiographic study. J Embryol Exp Morphol28: 87-115 Tay D, Hiscock J, Straznicky C (1982): Temporo-nasal asymmetry in the accretion of retinal ganglion cells in late larval and postmetamorphic Xenopus.

We are currently trying to look at the interactions between these difference components of the tPOC using in vitro confrontation assays. CONCLUSIONS The central role of the tPOC in axon guidance through the developing diencephalon has been described. This tract, wh ich originates as a chain of neurons with descending axons, forms the major pathway for longitudinal axon growth in the developing diencephalon. The reliance of retinal axons upon the tPOC has been examined by experimental deviation of the tract.

Axons from the cells grew at their usual time and in their normal descending fashion until they reached the discontinuity at the graft borders. At the graft borders, the axons commonly restored the continuity of the pathway, resulting in the formation of dramatically sinuous tracts. In some cases the grafted axons failed to rejoin the tract, while the remaining tPOC axons succeeded in forming a nearly normal tract by bypassing the graft. 2). Lm seetions taken through operated brains confirmed that the retinal axons still fasciculated with the rostral edge of the tPOC, which they followed either to the tectum or to a blind ending in the rostral diencephalon.

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