By Jean Bernard (auth.), Marcel Bessis, George Brecher (eds.)
Jean BERNARD * I should still wish to start with an assumption and a paradox. the belief is that leukemia is a disorder of a stem telephone characterised through pathologie changes of that phone and its progeny. All current learn and discussions are situated round the leukemic mobile. So is that this symposium, which might no longer occur with the exception of our basic curiosity within the leukemic telephone. this doesn't restrict, after all, attention of different definitions and different ways to the matter. by way of definition, then, the leukemic cells are irregular cells and their metabolism and services are presumed to be irregular. but, the class of the differing kinds of leukemias relies upon the features of standard cells. We speak of "lymphoblasts" and "myeloblasts" as fundamental mobilephone forms in leukemia. This ends up in a double paradox. within the first pi ace it's sincerely illogical to categorise irregular cells by way of their resemblance to general cells, when you consider that their very abnormality is composed in now not being common. but, as a moment paradox, the classifica ti on has had the satisfied outcome of ai ding us within the remedy and diagnosis of leukemia for the earlier 25 years. A extra special research exhibits that the outcome of this paradox are complicated: whereas there exists an invaluable correlation among mobile varieties, therapy and diagnosis, various difficulties and problems persist. the main critical of them concems the "unclassified leukemias" that are the cause of this reunion.
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Extra info for Unclassifiable Leukemias
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La chimiotherapiedes cancers (leucemies, hematosarcomes, tumeurs solides). 3rd ed. Paris: Expansion Seientifique Fran<;aise, 1974 16. : Prognostic faetors in acute leukaemias. In: Prognosis Factors in Human Acute Leukaemia. I vol. Oxford: Pergamon Press, 1974 (in press) 17. : Subdivision of c1assical varieties of aeute leukemias. Correlation with prognosis and eure expeetancy. Europ. J. Clin. Biol. Res. 16, 554, 1971 18. : Classifieation and subc1assifieation of acute leukemias eorrelated with c1inieal expression, therapeutie sensitivity and prognosis.